Subthalamic nucleus stimulation induces deficits in decoding emotional facial expressions in Parkinson’s disease
Identifieur interne : 000262 ( France/Analysis ); précédent : 000261; suivant : 000263Subthalamic nucleus stimulation induces deficits in decoding emotional facial expressions in Parkinson’s disease
Auteurs : K. Dujardin [France] ; S. Blairy [Belgique] ; L. Defebvre [France] ; P. Krystkowiak [France] ; U. Hess [Canada] ; S. Blond [France] ; A. Destée [France]Source :
- Journal of Neurology, Neurosurgery & Psychiatry [ 0022-3050 ] ; 2004-02.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- AC, anterior commissure, AMDP-AT, Association of Methodology and Documentation in Psychiatry-anxiety, DRS, dementia rating scale, EFE, emotional facial expression, Facial expression, MADRS, Montgomery and Asberg dementia rating scale, MMSE, mini-mental state examination, Nervous system diseases, PC, posterior commissure, Parkinson disease, Parkinson’s disease, STN stimulation, STN, subthalamic nucleus, Subthalamic nucleus, UPDRS, unified Parkinson’s disease rating scale, WAIS-R, Wechsler adult intelligence scale, revised, emotion processing, limbic system.
Abstract
Background: Bilateral subthalamic nucleus (STN) stimulation is recognised as a treatment for parkinsonian patients with severe levodopa related motor complications. Although adverse effects are infrequent, some behavioural disturbances have been reported. Objective: To investigate the consequences of STN stimulation on emotional information processing in Parkinson’s disease by assessing the performance of an emotional facial expression (EFE) decoding task in a group of patients before and after surgery. Methods: 12 non-demented patients with Parkinson’s disease were studied. They were assessed one month before surgery and three months after. Their ability to decode EFEs was assessed using a standardised quantitative task. Overall cognitive function, executive function, visuospatial perception, depression, and anxiety were also measured. Twelve healthy controls were matched for age, sex, and duration of education. Results: Before surgery, the patients showed no impairment in EFE decoding compared with the controls. Their overall cognitive status was preserved but they had a moderate dysexecutive syndrome. Three months after surgery, they had significant impairment of EFE decoding. This was not related to their overall cognitive status or to depression/anxiety scores. Visuospatial perception was not impaired. There was no change in the extent of the dysexecutive syndrome except for a reduction in phonemic word fluency. Conclusions: Bilateral STN stimulation disturbs negative emotional information processing in Parkinson’s disease. The impairment appears specific and unrelated to certain secondary variables. This behavioural complication of STN may have implications for the patient’s social life.
Url:
DOI: 10.1136/jnnp.2003.013656
Affiliations:
- Belgique, Canada, France
- Hauts-de-France, Nord-Pas-de-Calais, Québec, Région de Bruxelles-Capitale
- Bruxelles, Lille, Montréal
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ISTEX:F69EDCF3B7599D713046EE000A5A2ACFA13FD967Le document en format XML
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Although adverse effects are infrequent, some behavioural disturbances have been reported. Objective: To investigate the consequences of STN stimulation on emotional information processing in Parkinson’s disease by assessing the performance of an emotional facial expression (EFE) decoding task in a group of patients before and after surgery. Methods: 12 non-demented patients with Parkinson’s disease were studied. They were assessed one month before surgery and three months after. Their ability to decode EFEs was assessed using a standardised quantitative task. Overall cognitive function, executive function, visuospatial perception, depression, and anxiety were also measured. Twelve healthy controls were matched for age, sex, and duration of education. Results: Before surgery, the patients showed no impairment in EFE decoding compared with the controls. Their overall cognitive status was preserved but they had a moderate dysexecutive syndrome. Three months after surgery, they had significant impairment of EFE decoding. This was not related to their overall cognitive status or to depression/anxiety scores. Visuospatial perception was not impaired. There was no change in the extent of the dysexecutive syndrome except for a reduction in phonemic word fluency. Conclusions: Bilateral STN stimulation disturbs negative emotional information processing in Parkinson’s disease. The impairment appears specific and unrelated to certain secondary variables. This behavioural complication of STN may have implications for the patient’s social life.</div></front></TEI><affiliations><list><country><li>Belgique</li><li>Canada</li><li>France</li></country><region><li>Hauts-de-France</li><li>Nord-Pas-de-Calais</li><li>Québec</li><li>Région de Bruxelles-Capitale</li></region><settlement><li>Bruxelles</li><li>Lille</li><li>Montréal</li></settlement></list><tree><country name="France"><region name="Hauts-de-France"><name sortKey="Dujardin, K" sort="Dujardin, K" uniqKey="Dujardin K" first="K" last="Dujardin">K. Dujardin</name></region><name sortKey="Blond, S" sort="Blond, S" uniqKey="Blond S" first="S" last="Blond">S. Blond</name><name sortKey="Defebvre, L" sort="Defebvre, L" uniqKey="Defebvre L" first="L" last="Defebvre">L. Defebvre</name><name sortKey="Destee, A" sort="Destee, A" uniqKey="Destee A" first="A" last="Destée">A. Destée</name><name sortKey="Krystkowiak, P" sort="Krystkowiak, P" uniqKey="Krystkowiak P" first="P" last="Krystkowiak">P. 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